QM107

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Ligands
QM107

GtoPdb Ligand ID: 13527

Compound class: Peptide

Comment: QM107 is a synthetic short peptide that mimics the CD148-binding domain of human syndecan 2 (SDC2; P34741). It was designed to activate CD148 phosphatase activity as a mechanism to inhibit pro-angiogenic signalling as a novel treatment for neovascular age-related macular degeneration [1].

Summary
Biological activity
References
Structure

References
1. Arokiasamy S, Balderstone MJM, Shaik F, Cristante E, Moseley TC, Madoo A, Rizzi M, Bainbridge JW, Tsoyi K, Rosas IO et al.. (2025) QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age-related macular degeneration. Br J Pharmacol, 182 (4): 951-968. [PMID:39428594]

References

1. Arokiasamy S, Balderstone MJM, Shaik F, Cristante E, Moseley TC, Madoo A, Rizzi M, Bainbridge JW, Tsoyi K, Rosas IO et al.. (2025)
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age-related macular degeneration.
Br J Pharmacol, 182 (4): 951-968. [PMID:39428594]