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Synonyms: E-01AJ | E-10030 | E01AJ | E10030 | Fovista® | X-01E | X01E
Compound class:
Nucleic acid
Comment: Pegpleranib (E10030) is a 32-mer pegylated DNA aptamer that selectively binds to PDGF-BB and PDGF-AB homo- and hetero-dimers. It prevents PDGF binding to its cognate PDGF receptors. Blocking receptor activation leads to the death of capillary pericytes. This mechanism was investigated as a disruptor of vessel formation in neovascular age related macular degeneration. Pegpleranib is formulated as a sodium adduct for therapeutic administration (see DBSALT002614).
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Nucleic Acid Sequence  |
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| CAGGCUACGCGTAGAGCAUCATGATCCUGT | |
