miravirsen   Click here for help

GtoPdb Ligand ID: 13534

Synonyms: SPC-3649 | SPC3649
Compound class: Nucleic acid
Comment: Miravirsen (SPC-3649) is a 15 mer modified antisense oligonucleotide that binds to human miR-122 [4]. This mechanism disrupts miR-122-mediated protection of viral RNA from nuclease degradation [1-3]. Miravirsen was intended for the treatment of hepatitis C infection.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=CN(C2CC(C(COP(=S)(O)OC3C4C(N5C=NC6=C5N=CN=C6N)OC3(CO4)COP(=S)(O)OC7CC(N8C=CC(=NC8=O)N)OC7COP(=S)(O)OC9C%10C(N%11C=CC(=NC%11=O)N)OC9(CO)CO%10)O2)OP(=S)(O)OCC%12C(CC(N%13C=C(C)C(=O)NC%13=O)O%12)OP(=S)(O)OCC%14%15COC(C%14OP(=S)(O)OCC%16%17COC(C%16OP(=S)(O)OCC%18C(CC(N%19C=CC(=NC%19=O)N)O%18)OP(=S)(O)OCC%20C(CC(N%21C=NC%22=C%21N=CN=C%22N)O%20)OP(=S)(O)OCC%23%24COC(C%23OP(=S)(O)OCC%25C(CC(N%26C=NC%27=C%26N=CN=C%27N)O%25)OP(=S)(O)OCC%28%29COC(C%28OP(=S)(O)OCC%30C(CC(N%31C=C(C)C(=O)NC%31=O)O%30)OP(=S)(O)OCC%32%33COC(C%32OP(=S)(O)OCC%34%35COC(C%34O)C(N%36C=CC(=NC%36=O)N)O%35)C(N%37C=CC(=NC%37=O)N)O%33)C(N%38C=CC(=NC%38=O)N)O%29)C(N%39C=CC(=NC%39=O)N)O%24)C(N%40C=C(C)C(=O)NC%40=O)O%17)C(N%41C=NC%42=C%41N=C(N)NC%42=O)O%15)C(=O)NC1=O
Isomeric SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=S)(O)OC3C4C(OC3(CO4)COP(=S)(O)OC5CC(OC5COP(=S)(O)OC6C7C(OC6(CO7)CO)N8C=CC(=NC8=O)N)N9C=CC(=NC9=O)N)N%10C=NC%11=C(N=CN=C%11%10)N)OP(=S)(O)OCC%12C(CC(O%12)N%13C=C(C(=O)NC%13=O)C)OP(=S)(O)OCC%14%15COC(C%14OP(=S)(O)OCC%16%17COC(C%16OP(=S)(O)OCC%18C(CC(O%18)N%19C=CC(=NC%19=O)N)OP(=S)(O)OCC%20C(CC(O%20)N%21C=NC%22=C(N=CN=C%22%21)N)OP(=S)(O)OCC%23%24COC(C%23OP(=S)(O)OCC%25C(CC(O%25)N%26C=NC%27=C(N=CN=C%27%26)N)OP(=S)(O)OCC%28%29COC(C%28OP(=S)(O)OCC%30C(CC(O%30)N%31C=C(C(=O)NC%31=O)C)OP(=S)(O)OCC%32%33COC(C%32OP(=S)(O)OCC%34%35COC(C%34O)C(O%35)N%36C=CC(=NC%36=O)N)C(O%33)N%37C=CC(=NC%37=O)N)C(O%29)N%38C=CC(=NC%38=O)N)C(O%24)N%39C=CC(=NC%39=O)N)C(O%17)N%40C=C(C(=O)NC%40=O)C)C(O%15)N%41C=NC%42=C%41N=C(NC%42=O)N
InChI InChI=1S/C151H185N49O83P14S14/c1-60-26-193(140(215)182-119(60)203)87-21-66(74(258-87)34-245-290(225,304)281-110-102-130(199-58-171-94-114(161)165-55-168-117(94)199)268-150(110,44-239-102)50-252-291(226,305)272-65-20-86(187-13-6-79(153)174-134(187)209)256-72(65)33-243-286(221,300)277-105-97-125(262-144(105,37-201)38-234-97)189-15-8-81(155)176-136(189)211)271-285(220,299)241-30-73-67(22-88(257-73)194-27-61(2)120(204)183-141(194)216)273-293(228,307)253-51-151-45-240-103(131(269-151)200-59-172-95-118(200)180-132(162)181-123(95)207)111(151)283-297(232,311)254-52-149-43-238-101(129(267-149)196-29-63(4)122(206)185-143(196)218)109(149)280-289(224,303)244-32-71-64(19-85(255-71)186-12-5-78(152)173-133(186)208)270-284(219,298)242-31-76-69(24-90(260-76)197-56-169-92-112(159)163-53-166-115(92)197)275-294(229,308)249-47-147-41-236-99(127(265-147)191-17-10-83(157)178-138(191)213)107(147)279-288(223,302)247-36-77-70(25-91(261-77)198-57-170-93-113(160)164-54-167-116(93)198)276-295(230,309)250-48-146-40-235-98(126(264-146)190-16-9-82(156)177-137(190)212)106(146)278-287(222,301)246-35-75-68(23-89(259-75)195-28-62(3)121(205)184-142(195)217)274-292(227,306)251-49-148-42-237-100(128(266-148)192-18-11-84(158)179-139(192)214)108(148)282-296(231,310)248-46-145-39-233-96(104(145)202)124(263-145)188-14-7-80(154)175-135(188)210/h5-18,26-29,53-59,64-77,85-91,96-111,124-131,201-202H,19-25,30-52H2,1-4H3,(H,219,298)(H,220,299)(H,221,300)(H,222,301)(H,223,302)(H,224,303)(H,225,304)(H,226,305)(H,227,306)(H,228,307)(H,229,308)(H,230,309)(H,231,310)(H,232,311)(H2,152,173,208)(H2,153,174,209)(H2,154,175,210)(H2,155,176,211)(H2,156,177,212)(H2,157,178,213)(H2,158,179,214)(H2,159,163,166)(H2,160,164,167)(H2,161,165,168)(H,182,203,215)(H,183,204,216)(H,184,205,217)(H,185,206,218)(H3,162,180,181,207)
InChI Key OSOOBMBDIGGTCP-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Nucleic Acid Sequence Click here for help
CCATTGTCACACTCC
Download 2D Structure Click here for help
Canonical SMILES Download
Isomeric SMILES Download
InChI standard identifier Download
InChI standard key Download

Molecular structure representations generated using Open Babel