F598

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Ligands
F598

GtoPdb Ligand ID: 13554

Synonyms: SAR279356

Comment: F598 is a fully human IgG1 monoclonal antibody that targets poly-β-1,6-N-acetyl-d-glucosamine (PNAG) in microbial surfaces and biofilms [1-3]. It is being developed by Alopexx Pharma (Cambridge, USA) as an immune-mediated therapy for the prevention of nosocomial infections.

References
1. Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T et al.. (2013) Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A, 110 (24): E2209-18. [PMID:23716675]
2. Kelly-Quintos C, Cavacini LA, Posner MR, Goldmann D, Pier GB. (2006) Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosamine. Infect Immun, 74 (5): 2742-50. [PMID:16622211]
3. Soliman C, Walduck AK, Yuriev E, Richards JS, Cywes-Bentley C, Pier GB, Ramsland PA. (2018) Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine. J Biol Chem, 293 (14): 5079-5089. [PMID:29449370]

References

1. Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T et al.. (2013)
Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens.
Proc Natl Acad Sci U S A, 110 (24): E2209-18. [PMID:23716675]

2. Kelly-Quintos C, Cavacini LA, Posner MR, Goldmann D, Pier GB. (2006)
Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosamine.
Infect Immun, 74 (5): 2742-50. [PMID:16622211]

3. Soliman C, Walduck AK, Yuriev E, Richards JS, Cywes-Bentley C, Pier GB, Ramsland PA. (2018)
Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine.
J Biol Chem, 293 (14): 5079-5089. [PMID:29449370]