CMTX-101

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Ligands
CMTX-101

GtoPdb Ligand ID: 13582

Comment: CMTX-101 is a humanized monoclonal antibody against members of the DNABII family of bacterial DNA-binding proteins [1]. It disrupts bacterial biofilms and is being developed by Clarametyx Biosciences (Ohio, USA) as an immune-mediated therapy for serious infections associated with biofilms.

Summary
Biological activity
Clinical data
References

References
1. Rogers JV, Hall VL, McOsker CC. (2022) Crumbling the Castle: Targeting DNABII Proteins for Collapsing Bacterial Biofilms as a Therapeutic Approach to Treat Disease and Combat Antimicrobial Resistance. Antibiotics (Basel), 11 (1). [PMID:35052981]

References

1. Rogers JV, Hall VL, McOsker CC. (2022)
Crumbling the Castle: Targeting DNABII Proteins for Collapsing Bacterial Biofilms as a Therapeutic Approach to Treat Disease and Combat Antimicrobial Resistance.
Antibiotics (Basel), 11 (1). [PMID:35052981]