Synonyms: AZD-9150 | AZD9150 | ISIS STAT3Rx

Compound class: Nucleic acid

Comment: Danvatirsen (AZD9150) is a phosphorothioate antisense oligonucleotide that was designed to inhibit expression of signal transducer and activator of transcription 3 (STAT3) as an anti-tumour mechanism [2-4]. It contains 2′-4′ constrained ethyl (cEt)-modified residues that increase affinity for target mRNA [2].

Full sequence as provided in the agent's INN record is: all-P-ambo-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-5-methyl-P-thiocytidylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-5-methyl-P-thiouridylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioadenylyl-(3'→5')-P-thiothymidylyl-(3'→5')-P-thiothymidylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-5-methyl-P-thiocytidylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioadenylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioguanylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-5-methylcytidine, but we have been unable to resolve this to a SMILES or HELM notation.