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Synonyms: ALN-60212 | ALN-PCSsc | Leqvio®
inclisiran is an approved drug (EMA (2020), FDA & UK MHRA (2021))
Compound class:
Nucleic acid
Comment: Inclisiran is a small interfering RNA (siRNA) class drug that targets the proprotein convertase subtilisin kexin type 9 (PCSK9) mRNA, to reduce production of the PCSK9 protein [6].
Individual nucleotides are chemically modified to improve stability, and the structure has terminal GalNac (sugar) conjugation for hepatic targeted delivery. We have been unable to locate a full chemical SMILES for the drug, or its HELM notation. |
