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Synonyms: ALN-60212 | ALN-PCSsc | Leqvio®
inclisiran is an approved drug (EMA (2020), FDA & UK MHRA (2021))
Compound class:
Nucleic acid
Comment: Inclisiran is a small interfering RNA (siRNA) class drug that targets the proprotein convertase subtilisin kexin type 9 (PCSK9) mRNA, to reduce production of the PCSK9 protein [6].
Individual nucleotides are chemically modified to improve stability, and the structure has terminal GalNac (sugar) conjugation for hepatic targeted delivery. We have been unable to locate a full chemical SMILES for the drug, or its HELM notation. |
Nucleic Acid Sequence  |
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(3'-5')C=U=A-G-A-C-C-U-G-U-T-U-U-G-C-U-U-U-U-G-U-R1 (5'-3')A=A=G-A-U-C-U-G-G-A-C-A-A-A-A-C-G-A-A-A-A=C=A |
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