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Synonyms: CGT-003 | CGT003 | E2F Duplex Decoy
Compound class:
Nucleic acid
Comment: Edifoligide is an oligonucleotide decoy that binds to and inhibits activity of E2F transcription factors that regulate expression of genes controlling smooth muscle cell proliferation. This is proposed as a mechanism to reduce the progressive neointimal hyperplasia that contributes to vein graft failure following coronary artery bypass graft (CABG) surgery [2-4].
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