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Synonyms: CGT-003 | CGT003 | E2F Duplex Decoy
Compound class:
Nucleic acid
Comment: Edifoligide is an oligonucleotide decoy that binds to and inhibits activity of E2F transcription factors that regulate expression of genes controlling smooth muscle cell proliferation. This is proposed as a mechanism to reduce the progressive neointimal hyperplasia that contributes to vein graft failure following coronary artery bypass graft (CABG) surgery [2-4].
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Nucleic Acid Sequence  |
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(3'-5')d(P-thio)(CTAGATTTCCCGCG) (5'-3')d(P-thio)(TAAAGGGCGCCTAG |
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| HELM Notation |
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| RNA1{[dR](G).[sp][dR](A).[sp][dR](T).[sp][dR](C).[sp][dR](C).[sp][dR](G).[sp][dR](C).[sp][dR](G).[sp][dR](G).[sp][dR](G).[sp][dR](A).[sp][dR](A).[sp][dR](A).[sp][dR](T)}|RNA2{[dR](C).[sp][dR](T).[sp][dR](A).[sp][dR](G).[sp][dR](A).[sp][dR](T).[sp][dR](T).[sp][dR](T).[sp][dR](C).[sp][dR](C).[sp][dR](C).[sp][dR](G).[sp][dR](C).[sp][dR](G)}$$$$ | |
