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Synonyms: MRG-201 | MRG201
Compound class:
Nucleic acid
Comment: Remlarsen (MRG-201) is a miRNA class ligand that is a synthetic mimic of microRNA-29 (miR-29b). It is proposed as an anti-fibrotic agent.
We have been unable to locate a full chemical SMILES for the ligand, or its HELM notation. |
| No information available. |
Summary of Clinical Use  |
| MRG-201 is being evaluated for therapeutic efficacy as a reducer of collagen synthesis (and other pro-fibrotic proteins) for benefit in mitigating kelloid formation. It may also be applicable in other fibrotic conditions [1]. |
| Clinical Trials | |||||
| Clinical Trial ID | Title | Type | Source | Comment | References |
| NCT02603224 | Safety, Tolerability and Pharmacokinetic Study of MRG-201 in Healthy Volunteers | Phase 1 Interventional | miRagen Therapeutics, Inc. | ||
| NCT03601052 | Efficacy, Safety, and Tolerability of Remlarsen (MRG-201) Following Intradermal Injection in Subjects With a History of Keloids | Phase 2 Interventional | miRagen Therapeutics, Inc. | ||
