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Synonyms: BT-200 | BT200
Compound class:
Nucleic acid
Comment: Rondaptivon pegol (BT200) belongs to the aptamer class of nucleic acid drugs/ligands. It binds to the A1 (platelet, heparin and collagen binding) domain of von Willebrand factor (vWF) [3]. Blocking interaction with receptors on platelets reduces platelet-mediated thrombogenesis [2]. Aptamer binding also prolongs the plasma half-life of factor VIII (FVIII) , which is mediated by interaction with the vWF D'/D3 domain, so offers potential in the treatment of FVIII deficiency hemophilia (hemophilia A) [1].
We have been unable to locate a full chemical SMILES for the ligand, or its HELM notation. |
| No information available. |
Summary of Clinical Use  |
| Rondaptivon pegol (BT200) is a clinical candidate that regulates primary hemostasis and clotting. |
| Clinical Trials | |||||
| Clinical Trial ID | Title | Type | Source | Comment | References |
| NCT04677803 | BT200 in Hereditary Bleeding Disorders | Phase 2 Interventional | Medical University of Vienna | ||
| NCT04103034 | A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers | Phase 1 Interventional | Band Therapeutics | 2 | |
