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Synonyms: AL-001 | AL001
Compound class:
Antibody
Comment: Latozinemab (AL001) is an anti-sortilin 1 (SORT1) monoclonal antibody. It is proposed to elevate progranulin levels by inhibiting the SORT1-mediated degradation pathway for progranulin (PGRN). This mechanism is being investigated as a disease‐modifying therapy for patients with frontotemporal dementia caused by loss-of-function mutations in GRN.
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