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Synonyms: endozepine [7]
Compound class:
Endogenous peptide in human, mouse or rat
Comment: Diazepam binding inhibitor/Acyl-CoA-binding protein (ACBP) an a 11kD peptide with multiple biological actions [1,3,5]. It is reported to bind to thiol esters of long fatty acids and coenzyme A. It also displaces diazepam from the benzodiazepine binding domain of type A gamma-aminobutyric acid GABAA receptors [2,4], which suggests that it may act as an allosteric GABAA modulator.
An in vivo CRISPR activation screening study identified ACBP as a component of a lipid metabolic pathway that is involved in cancer bone metastasis [6].
Species: Human
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