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Synonyms: LY-3819469 | LY3819469
Compound class:
Nucleic acid
Comment: Lepodisiran (LY3819469) is an apolipoprotein A synthesis reducer. It is a GalNac-conjugated short interfering RNA (siRNA) that was designed to treat atherosclerotic cardiovascular disease in patients with elevated lipoprotein A [1-2].
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| References |
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1. Sosnowska B, Surma S, Banach M. (2022)
Targeted Treatment against Lipoprotein (a): The Coming Breakthrough in Lipid Lowering Therapy. Pharmaceuticals (Basel), 15 (12). [PMID:36559024] |
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2. Thau H, Neuber S, Emmert MY, Nazari-Shafti TZ. (2024)
Targeting Lipoprotein(a): Can RNA Therapeutics Provide the Next Step in the Prevention of Cardiovascular Disease?. Cardiol Ther, 13 (1): 39-67. [PMID:38381282] |
