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Synonyms: TQJ-230 | TQJ230
Compound class:
Nucleic acid
Comment: Pelacarsen (TQJ230) is an apolipoprotein A synthesis reducer. It is a liver-targeted antisense oligonucleotide that was designed to lower serum lipoprotein A as a mechanism to reduce atherosclerotic cardiovascular disease risk [1-2].
We have been unable to locate a full chemical SMILES for the drug, or its HELM notation. We provide the basic nucleic acid structure for the molecule here. Full specifications for all modifications are available from its INN record. |
| References |
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1. Karwatowska-Prokopczuk E, Lesogor A, Yan JH, Hurh E, Hoenlinger A, Margolskee A, Xia S, Tsimikas S. (2023)
Efficacy and safety of pelacarsen in lowering Lp(a) in healthy Japanese subjects. J Clin Lipidol, 17 (1): 181-188. [PMID:36529659] |
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2. Yeang C, Karwatowska-Prokopczuk E, Su F, Dinh B, Xia S, Witztum JL, Tsimikas S. (2022)
Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol, 79 (11): 1035-1046. [PMID:35300814] |
