AER002

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Ligands
AER002

GtoPdb Ligand ID: 13723

Synonyms: AER-002 | P2G3

Comment: AER002 is a long-acting fully human anti-SARS-CoV-2 spike protein monoclonal antibody that blocks spike-ACE2 interactions, viral attachment and infection of host cells. It was isolated from post-COVID-19 patient plasma [1].

Summary
Biological activity
Clinical data
References

References
1. Fenwick C, Turelli P, Ni D, Perez L, Lau K, Herate C, Marlin R, Lana E, Pellaton C, Raclot C et al.. (2022) Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys. Nat Microbiol, 7 (9): 1376-1389. [PMID:35879526]
2. Moullan N, Asiago J, Stecco K, Hadi S, Albizem M, Tieu H, Hock B, Fenwick C, Lin K, Lengsfeld T et al.. (2024) A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies. Infect Dis Ther, 13 (1): 173-187. [PMID:38221576]

References

1. Fenwick C, Turelli P, Ni D, Perez L, Lau K, Herate C, Marlin R, Lana E, Pellaton C, Raclot C et al.. (2022)
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys.
Nat Microbiol, 7 (9): 1376-1389. [PMID:35879526]

2. Moullan N, Asiago J, Stecco K, Hadi S, Albizem M, Tieu H, Hock B, Fenwick C, Lin K, Lengsfeld T et al.. (2024)
A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies.
Infect Dis Ther, 13 (1): 173-187. [PMID:38221576]