petrelintide

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petrelintide

GtoPdb Ligand ID: 13804

Synonyms: ZP-8396 | ZP8396

Compound class: Peptide

Comment: Petrelintide (ZP8396) is a long-acting (lipidated) analogue of the anorexigenic peptide amylin [1]. It was developed by Zealand Pharma for the treatment of type 2 diabetes and obesity. Amylin analogues are proposed to provide GLP-1-like efficacy with reduced propensity for side effects.

Summary
Biological activity
Clinical data
References
Structure

References
1. Olsen MB, Hovelmann U, Griffin J, Knudsen KM, Johansen T, Kendall D, Heise T. (2023) 92-LB: Safety, Tolerability, and Clinical Effects of ZP8396, a Novel Long-Acting Amylin Analog—A Single Ascending Dose Trial. Diabetes, 72 (Supplement_1). DOI: 10.2337/db23-92-LB

References

1. Olsen MB, Hovelmann U, Griffin J, Knudsen KM, Johansen T, Kendall D, Heise T. (2023)
92-LB: Safety, Tolerability, and Clinical Effects of ZP8396, a Novel Long-Acting Amylin Analog—A Single Ascending Dose Trial.
Diabetes, 72 (Supplement_1). DOI: 10.2337/db23-92-LB