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petrelintide   Click here for help

GtoPdb Ligand ID: 13804

Synonyms: ZP-8396 | ZP8396
Compound class: Peptide
Comment: Petrelintide (ZP8396) is a long-acting (lipidated) analogue of the anorexigenic peptide amylin [1]. It was developed by Zealand Pharma for the treatment of type 2 diabetes and obesity. Amylin analogues are proposed to provide GLP-1-like efficacy with reduced propensity for side effects.
Peptide Sequence Click here for help
ERDGTATKATERLAXFLQRSSFGAILSSTEVGSNTP-NH2
Chemical Modification
Amide bridge between Asp3-Lys8
Glu1 = HO2C-[CH2]18-CO-γ-L-Glu
X = α-(2S)-2-aminoadipic acid
Gly23 = methyl-Gly
Ile25 = methyl-L-Ile
Pro36 = (4R)-4-hydroxyl-L-Pro-NH2