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pigment epithelium-derived factor   Click here for help

GtoPdb Ligand ID: 13831

Compound class: Endogenous peptide in human, mouse or rat
Comment: The pigment epithelium-derived factor (PEDF) encoded by SERPINF1 is an endogenous ligand of PNPLA2 (a.k.a.adipose triglyceride lipase, ATGL) [7]. PEDF a non-inhibitory member of the serine protease inhibitor (SERPIN) superfamily that is expressed on the surface of retinal epithelial cells [2], and appears to be required for photoreceptor and retinal neuron cell survival [4,8]. Age-related loss of PEDF in the retina is associated with retinal damage and conditions like AMD.

Peptide fragment derivatives of PEDF have demonstrated protective effects in experimental models of degenerative retinal diseases [3,5].
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Baek YB, Kwon HJ, Sharif M, Lim J, Lee IC, Ryu YB, Lee JI, Kim JS, Lee YS, Kim DH et al.. (2022)
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus.
Signal Transduct Target Ther, 7 (1): 367. [PMID:36253361]
2. Becerra SP, Fariss RN, Wu YQ, Montuenga LM, Wong P, Pfeffer BA. (2004)
Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution.
Exp Eye Res, 78 (2): 223-34. [PMID:14729355]
3. Bernardo-Colón A, Bighinati A, Parween S, Debnath S, Piano I, Adani E, Corsi F, Gargini C, Vergara N, Marigo V et al.. (2025)
H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration.
Commun Med (Lond), 5 (1): 81. [PMID:40118996]
4. Cayouette M, Smith SB, Becerra SP, Gravel C. (1999)
Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations.
Neurobiol Dis, 6 (6): 523-32. [PMID:10600408]
5. Chader GJ. (2005)
Surmountable challenges in translating pigment epithelium-derived factor (PEDF) therapy from animal models to clinical trials for retinal degenerations.
Retina, 25 (8 Suppl): S29-S30. [PMID:16374323]
6. Dasgupta A, Gangai S, Narayan R, Kapoor S. (2023)
Mapping the Lipid Signatures in COVID-19 Infection: Diagnostic and Therapeutic Solutions.
J Med Chem, 66 (21): 14411-14433. [PMID:37899546]
7. Subramanian P, Notario PM, Becerra SP. (2010)
Pigment epithelium-derived factor receptor (PEDF-R): a plasma membrane-linked phospholipase with PEDF binding affinity.
Adv Exp Med Biol, 664: 29-37. [PMID:20237999]
8. Takita H, Yoneya S, Gehlbach PL, Duh EJ, Wei LL, Mori K. (2003)
Retinal neuroprotection against ischemic injury mediated by intraocular gene transfer of pigment epithelium-derived factor.
Invest Ophthalmol Vis Sci, 44 (10): 4497-504. [PMID:14507898]