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ifinatamab deruxtecan   Click here for help

GtoPdb Ligand ID: 13850

Synonyms: DS-7300 | I-DXd
Compound class: Antibody
Comment: Ifinatamab deruxtecan (DS-7300) is a B7-H3 (CD276)-targeting antibody-drug conjugate (ADC) [1]. B7-H3 is an immuno-oncology molecular target in solid tumours. The deruxtecan conjugate is a camptothecin derivative that is used as a cytotoxic DNA topoisomerase 1 payload.
References
1. Fabrizio FP, Muscarella LA, Rossi A. (2024)
B7-H3/CD276 and small-cell lung cancer: What's new?.
Transl Oncol, 39: 101801. [PMID:37865049]