manfidokimab

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Ligands
manfidokimab

GtoPdb Ligand ID: 13888

Synonyms: AK-120 | AK120

Compound class: Antibody

Comment: Manfidokimab (AK120) is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha (IL-4Rα) subunit of the IL-4 and IL-13 receptor complexes. It was designed to block pathological T helper 2 (Th2)-mediated inflammatory responses initiated by the IL-4 and IL-13 cytokines.

Summary
Biological activity
Clinical data
References

References
1. Wynne CJ, Cole A, Lemech C, Wang G, Zhang Y, Chen B, Wang M, Li B, Xia M, Sinclair R. (2023) Safety, Pharmacokinetics and Preliminary Efficacy of IL4-Rα Monoclonal Antibody AK120 in Both Healthy and Atopic Dermatitis Subjects: A Phase I, Randomized, Two-Part, Double-Blind, Placebo-Controlled, Dose-Escalation, First-In-Human Clinical Study. Dermatol Ther (Heidelb), 13 (10): 2357-2373. [PMID:37668898]

References

1. Wynne CJ, Cole A, Lemech C, Wang G, Zhang Y, Chen B, Wang M, Li B, Xia M, Sinclair R. (2023)
Safety, Pharmacokinetics and Preliminary Efficacy of IL4-Rα Monoclonal Antibody AK120 in Both Healthy and Atopic Dermatitis Subjects: A Phase I, Randomized, Two-Part, Double-Blind, Placebo-Controlled, Dose-Escalation, First-In-Human Clinical Study.
Dermatol Ther (Heidelb), 13 (10): 2357-2373. [PMID:37668898]