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CIGB-552   Click here for help

GtoPdb Ligand ID: 13896

Synonyms: CIGB552
Compound class: Peptide
Comment: CIGB-552 is a cell-penetrating peptide that exterts a stabilising effect on the COMM domain-containing 1 (COMMD1) protein [1,3]. COMMD1 is a multi-function protein with involvement in copper homeostasis, sodium transport, and regulation of NF-κB signaling [2].
Bioactivity Comments
In vitro anti-tumour effects of CIGB-552 that are COMMD1-dependent have been reported [1,3]
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
copper metabolism domain containing 1 Hs None Binding - - - 3
⤷ [3]