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Synonyms: Ionis-tmprss6-lrx | ISIS 702843 | ISIS-702843 | ISIS702843
Compound class:
Nucleic acid
Comment: Sapablursen (ISIS 702843) is a N-acetyl galactosamine (GalNAc3) modified antisense oligonucleotide that is designed to reduce production of transmembrane protease serine 6 messenger (TMPRSS6) protein [1], as a mechanism to elevate expression of hepcidin and stabilise iron homeostasis in hematologic diseases.
Primary nucleotide sequence is provided without annotation of base and bond modifications, or glycan conjugation. |
