GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

sapablursen   Click here for help

GtoPdb Ligand ID: 13914

Synonyms: Ionis-tmprss6-lrx | ISIS 702843 | ISIS-702843 | ISIS702843
Compound class: Nucleic acid
Comment: Sapablursen (ISIS 702843) is a N-acetyl galactosamine (GalNAc3) modified antisense oligonucleotide that is designed to reduce production of transmembrane protease serine 6 messenger (TMPRSS6) protein [1], as a mechanism to elevate expression of hepcidin and stabilise iron homeostasis in hematologic diseases.
Primary nucleotide sequence is provided without annotation of base and bond modifications, or glycan conjugation.
Nucleic Acid Sequence Click here for help
(3'-5')cuuuattccaaagggcagcu