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enlicitide   Click here for help

GtoPdb Ligand ID: 13944

Compound class: Peptide
Comment: Enlicitide (MK-0616) is a macrocyclic peptide oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor [2]. PCSK9 is a dyslipidemia drug target. Enlicitide binds to PCSK9 and prevents its protein-protein interaction with the low-density lipoprotein receptor, which ultimately reduces plasma LDL-C concentration. Formulated as the chloride salt or decanoate adduct [5] for clinical use. The core peptide sequence is cyclo-Ala-D-Ala-Phe-Trp-Pro-Thr-Tyr-Pro-NH
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C[C@H]1C(=O)N[C@H](CNC(=O)CCCCC[N+](C)(C)C)C(=O)N[C@H]2CC3=CC=CC(=C3)CNC(=O)CO[C@H]4CCN5[C@@H]4C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC6=CC=C(C=C6)OC)C(=O)N7CCC[C@@]7(C)C(=O)NCCC8=CC=C(C=C8)CN(CCCCCCN9C=C(C[C@@H](C5=O)NC2=O)C%10=C9C=CC(=C%10)F)C(=O)CCC(=O)N1
Isomeric SMILES C[C@H]1C(=O)N[C@@H](C(=O)N[C@H]2CC3=CC(=CC=C3)CNC(=O)CO[C@H]4CCN5[C@@H]4C(=O)N[C@H](C(=O)N[C@H](C(=O)N6CCC[C@]6(C(=O)NCCC7=CC=C(CN(CCCCCCN8C=C(C[C@@H](C5=O)NC2=O)C9=C8C=CC(=C9)F)C(=O)CCC(=O)N1)C=C7)C)CC%10=CC=C(C=C%10)OC)[C@@H](C)O)CNC(=O)CCCCC[N+](C)(C)C
InChI InChI=1S/C82H109FN14O15/c1-51-74(103)91-65(47-86-68(99)19-11-10-14-40-97(4,5)6)76(105)88-62-43-56-17-15-18-57(41-56)46-85-70(101)50-112-67-33-39-95-73(67)78(107)92-72(52(2)98)77(106)90-63(42-54-24-27-60(111-7)28-25-54)80(109)96-38-16-34-82(96,3)81(110)84-35-32-53-20-22-55(23-21-53)48-94(71(102)31-30-69(100)87-51)37-13-9-8-12-36-93-49-58(44-64(79(95)108)89-75(62)104)61-45-59(83)26-29-66(61)93/h15,17-18,20-29,41,45,49,51-52,62-65,67,72-73,98H,8-14,16,19,30-40,42-44,46-48,50H2,1-7H3,(H8-,84,85,86,87,88,89,90,91,92,99,100,101,103,104,105,106,107,110)/p+1/t51-,52+,62-,63-,64-,65+,67-,72-,73-,82-/m0/s1
InChI Key ZJMSWDDEBKNMLX-HMPNVHCESA-O

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
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Summary of Clinical Use Click here for help
Enlicitide (MK-0616) is a clinical lead for the treatment of hypercholesterolemia/atherosclerotic cardiovascular disease. It was found to reduce plasma LDL-C in early clinical studies in healthy participants [3], and in those with hypercholesterolemia [1], and appears to be well tolerated. Larger clinical trials are ongoing.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT06008756 Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes Phase 3 Interventional Merck Sharp & Dohme LLC
NCT06450366 A Study to Evaluate the Efficacy and Safety of Enlicitide Decanoate (MK-0616, Oral PCSK9 Inhibitor) Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018) CORALreef AddOn Phase 3 Interventional Merck Sharp & Dohme LLC
NCT06492291 Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension Phase 3 Interventional Merck Sharp & Dohme LLC
NCT05070390 A Study of MK-0616 in Participants With Moderate Renal Impairment (MK-0616-007) Phase 1 Interventional Merck Sharp & Dohme LLC
NCT05261126 A Study of the Efficacy and Safety of MK-0616 (Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-008) Phase 2 Interventional Merck Sharp & Dohme LLC 1