From August 18th 2026, GtoPdb will require users to register to use the website. Please see our blog post for more information.

patritumab deruxtecan   Click here for help

GtoPdb Ligand ID: 14121

Synonyms: HER3-DXd | MK-1022 | U3-1402
Immunopharmacology Ligand
Compound class: Antibody
Comment: Patritumab deruxtecan (MK-1022; HER3-DXd) is an anti-Erb-B2 receptor tyrosine kinase 3 (ERBB3; HER3) antibody-drug conjugate. The conjugate is a camptothecin derivative that inhibits topoisomerase I activity to kill tumour cells [5]. HER3 is a key dimerisation partner for HER receptors. Antibody binding induces rapid receptor internalisation and inhibits HER signalling.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
11093 patritumab deruxtecan
Synonyms Click here for help
HER3-DXd | MK-1022 | U3-1402
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 964
Other databases
GtoPdb PubChem SID 518520748
Search PubMed clinical trials patritumab deruxtecan
Search PubMed titles patritumab deruxtecan
Search PubMed titles/abstracts patritumab deruxtecan