RESP-X

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Ligands
RESP-X

GtoPdb Ligand ID: 14217

Synonyms: COT-143 | INFEX702

Compound class: Antibody

Comment: RESP-X is a humanized monoclonal antibody targeting the PcrV protein of Pseudomonas aeruginosa. It is being developed as an anti-virulence therapy for P. aeruginosa infections in patients with non-cystic fibrosis bronchiectasis.

Summary
Biological activity
Clinical data
References

References
1. Numata S, Hara T, Izawa M, Okuno Y, Sato Y, Yamane S, Maki H, Sato T, Yamano Y. (2024) Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas aeruginosa infection via inhibition of toxin translocation by the type III secretion system. Antimicrob Agents Chemother, 68 (10): e0069424. [PMID:39269189]

References

1. Numata S, Hara T, Izawa M, Okuno Y, Sato Y, Yamane S, Maki H, Sato T, Yamano Y. (2024)
Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas aeruginosa infection via inhibition of toxin translocation by the type III secretion system.
Antimicrob Agents Chemother, 68 (10): e0069424. [PMID:39269189]