ribaxamase

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Ligands
ribaxamase

GtoPdb Ligand ID: 14218

Synonyms: P3A | SYN-004

Compound class: Peptide

Comment: Ribaxamase is an orally delivered β-lactamase enzyme, under clinical development as a protective agent against dysbiosis of the gastrointestinal tract caused by some antibacterial drugs [1]. The peptide sequence for ribaxamase is available from its INN record.

Summary
Biological activity
Clinical data
References
Structure

Bioactivity Comments
Ribaxamase hydrolyses penicillin and cephalosporin (β-lactam) antibacterials in vitro [1]. The same study found that ribaxamase degraded ceftriaxone in the gastrintestinal tract of dogs and protected the microbiome of pigs from ceftriaxone-induced changes. The results from two Phase 2 clinical studies (NCT02419001 and NCT02473640) confirmed that ribaxamase also degrades ceftriaxone in the human intestine [3].

Bioactivity Comments

Ribaxamase hydrolyses penicillin and cephalosporin (β-lactam) antibacterials in vitro [1]. The same study found that ribaxamase degraded ceftriaxone in the gastrintestinal tract of dogs and protected the microbiome of pigs from ceftriaxone-induced changes. The results from two Phase 2 clinical studies (NCT02419001 and NCT02473640) confirmed that ribaxamase also degrades ceftriaxone in the human intestine [3].