cloacaenodin

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Ligands
cloacaenodin

GtoPdb Ligand ID: 14251

Compound class: Peptide

Comment: Cloacaenodin is an antimicrobial lasso peptide discovered using genome mining in species of the Enterobacter cloacae complex (ECC) [2].

Summary
Biological activity
Clinical data
References
Structure

No information available.

No information available.

Mechanism Of Action and Pharmacodynamic Effects
Cloacaenodin inhibits RNA polymerase, with a narrow and selective spectrum of antibacterial activity that is determined by cellular uptake of the compound. The transport pathway of cloacaenodin in susceptible enterobacteria has been elucidated, with a novel TonB-dependent transporter CloU identified as the outer membrane receptor and SbmA, as the inner membrane receptor [1].

Mechanism Of Action and Pharmacodynamic Effects

Cloacaenodin inhibits RNA polymerase, with a narrow and selective spectrum of antibacterial activity that is determined by cellular uptake of the compound. The transport pathway of cloacaenodin in susceptible enterobacteria has been elucidated, with a novel TonB-dependent transporter CloU identified as the outer membrane receptor and SbmA, as the inner membrane receptor [1].