GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
|
Compound class:
Antibody
Comment: Delpacibart is an anti-TFRC (transferrin receptor) monoclonal antibody. It is being used to deliver conjugated antisense oligonucleotides (ASOs) to target tissues as treatment options for muscular dystrophies [1]. Antibody peptide sequence analysis reveals matches to claims in patent US10913800B2 [2]. Data provided in the patent show that the antibody binds to human and monkey TFRC but does not bind to transferrin receptor 2 (TFR2).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||
