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compound 5a [PMID: 41246830]   Click here for help

GtoPdb Ligand ID: 14288

Compound class: Peptide
Comment: This compound is a peptidomimetic, covalent and reversible inhibitor of the main protease (Mpro) of coronaviruses SARS-CoV, SARS-CoV-2 and MERS-CoV [1-2]. It does not inhibit human cathepsin L (hCatL).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C=CC(=O)[C@@H](C)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2
Isomeric SMILES C[C@H](C(=O)C=C)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2
InChI InChI=1S/C22H24N2O4/c1-3-20(25)16(2)23-21(26)19(14-17-10-6-4-7-11-17)24-22(27)28-15-18-12-8-5-9-13-18/h3-13,16,19H,1,14-15H2,2H3,(H,23,26)(H,24,27)/t16-,19-/m1/s1
InChI Key NUIYZIJXWYTVNN-VQIMIIECSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Caffrey CR, O'donoghue AJ, Serafim MSM. (2024)
Methods for inhibition of viral infection.
Patent number: WO2024263680A1. Assignee: University of California Berkeley, University of California San Diego UCSD. Priority date: 20/06/2024. Publication date: 26/12/2024.
2. Sá Magalhães Serafim M, Kronenberger T, Francisco KR, de Sousa Reis EV, Gonçalves de Oliveira E, Marcelino E Oliveira FK, Serraglio Fortes I, Maciel Fernandes TH, Barbosa da Silva E, Fajtova P et al.. (2025)
Discovery of benzyl carbamate inhibitors of coronavirus Mpro enzymes from a legacy collection of cysteine protease inhibitors.
J Enzyme Inhib Med Chem, 40 (1): 2585619. [PMID:41246830]