GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

posdinemab   Click here for help

GtoPdb Ligand ID: 14292

Synonyms: hPT3 [3] | JNJ-3657 | JNJ-63733657 | JNJ3657 | JNJ63733657
Compound class: Antibody
Comment: Posdinemab (JNJ-63733657) is a humanized IgG1/kappa monoclonal antibody that targets phosphorylated microtubule-associated protein tau. It binds to phosphorylated threonine residues in the protein's proline-rich domain. JNJ-63733657 was humanized from mouse parental antibody PT3 [3]. Phospho-tau reduction is proposed for the treatment of Alzheimer's disease.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
microtubule associated protein tau Hs Antibody Binding >10.5 pKd - 3
⤷ pKd >10.5 (Kd <3x10-11 M) [3]
Description: Binding affinity for phospho-Tau (pT212/T217) paired helical filaments determined by SPR