D-GL13K

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Ligands
D-GL13K

GtoPdb Ligand ID: 14298

Synonyms: DGL13K

Compound class: Peptide

Comment: D-GL13K is the D-enantiomer of GL13K, an antimicrobial peptide derived from the sequence of human salivary protein BPIFA2 (BPI fold containing family A member 2) [1-2]. D-GL13K demonstrates both Gram-positive and Gram-negative antibacterial activity, is resistant to proteases and inhibits bacterial biofilm formation [4].

Summary
Biological activity
References
Structure

Bioactivity Comments
D-GL13K has in vitro activity against extended-spectrum beta-lactamase (ESBL)-producing and Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (MICs 16-32 μg/ml), MDR and XDR P. aeruginosa, and XDR Acinetobacter baumannii carrying metallo-beta-lactamases (MICs 8-32 μg/ml) [3].

Bioactivity Comments

D-GL13K has in vitro activity against extended-spectrum beta-lactamase (ESBL)-producing and Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (MICs 16-32 μg/ml), MDR and XDR P. aeruginosa, and XDR Acinetobacter baumannii carrying metallo-beta-lactamases (MICs 8-32 μg/ml) [3].