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Synonyms: DGL13K
Compound class:
Peptide
Comment: D-GL13K is the D-enantiomer of GL13K, an antimicrobial peptide derived from the sequence of human salivary protein BPIFA2 (BPI fold containing family A member 2) [1-2]. D-GL13K demonstrates both Gram-positive and Gram-negative antibacterial activity, is resistant to proteases and inhibits bacterial biofilm formation [4].
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| References |
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1. Abdolhosseini M, Nandula SR, Song J, Hirt H, Gorr SU. (2012)
Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity. Peptides, 35 (2): 231-8. [PMID:22484285] |
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2. Gorr SU, Abdolhosseini M, Shelar A, Sotsky J. (2011)
Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein. Biochem Soc Trans, 39 (4): 1028-32. [PMID:21787342] |
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3. Gorr SU, Brigman HV, Anderson JC, Hirsch EB. (2022)
The antimicrobial peptide DGL13K is active against drug-resistant gram-negative bacteria and sub-inhibitory concentrations stimulate bacterial growth without causing resistance. PLoS One, 17 (8): e0273504. [PMID:36006947] |
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4. Hirt H, Hall JW, Larson E, Gorr SU. (2018)
A D-enantiomer of the antimicrobial peptide GL13K evades antimicrobial resistance in the Gram positive bacteria Enterococcus faecalis and Streptococcus gordonii. PLoS One, 13 (3): e0194900. [PMID:29566082] |
