rinatabart sesutecan

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Ligands
rinatabart sesutecan

GtoPdb Ligand ID: 14353

Synonyms: GEN1184 | PRO1184 | Rina-S

Compound class: Antibody

Comment: Rinatabart sesutecan (GEN1184; PRO1184; Rina-S) is a folate receptor alpha (FRα) antibody-drug conjugate. The payload is the topoisomerase I inhibitor exatecan (PubChem CID 151115). Designed to target ovarian and endometrial cancers that are overexpressing FRα.

Summary
Biological activity
Clinical data
References

References
1. Call JA, Orr DW, Anderson IC, Richardson DL, Chen Z, Ma S, Hunder NNH, Hamilton EP. (2023) Phase 1/2 study of PRO1184, a novel folate receptor alpha-directed antibody-drug conjugate, in patients with locally advanced and/or metastatic solid tumors. J Clin Oncol,. DOI: 10.1200/JCO.2023.41.16_suppl.TPS315

References

1. Call JA, Orr DW, Anderson IC, Richardson DL, Chen Z, Ma S, Hunder NNH, Hamilton EP. (2023)
Phase 1/2 study of PRO1184, a novel folate receptor alpha-directed antibody-drug conjugate, in patients with locally advanced and/or metastatic solid tumors.
J Clin Oncol,. DOI: 10.1200/JCO.2023.41.16_suppl.TPS315