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povetacicept   Click here for help

GtoPdb Ligand ID: 14426

Synonyms: ALPN-303 | TACI vTD-Fc
Immunopharmacology Ligand
Compound class: Peptide
Comment: Povetacicept (ALPN-303) is a Fc fusion protein that contains a variant TACI domain of the TNFRSF13B receptor for the peptide cytokines B cell activating factor (BAFF; TNFSF13B) and a proliferation-inducing ligand (APRIL; TNFSF13) [2]. It functionally antagonises the cellular signalling pathways of these ligands via TNFRSF13B on B cells.
In the peptide sequence provided the TACI domain is amino acids 1-43, with a short linker (GSGGGGS 44-50 ) and the remainder being the Fc domain. The functional peptide is a dimer, linked by inter-chain disulphide bridges.
Classification Click here for help
Compound class Peptide
International Nonproprietary Names Click here for help
INN number INN
12264 povetacicept
Synonyms Click here for help
ALPN-303 | TACI vTD-Fc
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1378
Other databases
CAS Registry No. 2490217-42-8 (source: WHO INN record)
GtoPdb PubChem SID 523352218
Search PubMed clinical trials povetacicept
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