Bioactivity Comments

The C20 fatty acid (lipid) modification generates a degron with longer-persisiting degrading activity, whereas the C16 modified peptide acheives a greater reduction in ATXN2 levels at lower doses [1]. Degron-mediated ATXN2 reduction improves survival and motor function in a mouse ALS model.

Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference ataxin 2 Hs None Binding - - - 1 ⤷ Degron degrader [1]