ATXN2 degron

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Ligands
ATXN2 degron

GtoPdb Ligand ID: 14454

Compound class: Peptide

Comment: This is a fatty acid-modified peptide that acts as a degron (promotes degradation) of the ataxin 2 (ATXN2) protein [1].

Summary
Biological activity
References
Structure

References
1. Zhu J, Wang L, Wen W, Kojic L, Cynader M et al.. (2025) Degron peptide targeting Ataxin-2 mitigates neurodegeneration and neuroinflammation Progression in a TDP-43 Mouse Model of ALS. Authorea, Preprint. DOI: 10.22541/au.175023624.41125652/v1

References

1. Zhu J, Wang L, Wen W, Kojic L, Cynader M et al.. (2025)
Degron peptide targeting Ataxin-2 mitigates neurodegeneration and neuroinflammation Progression in a TDP-43 Mouse Model of ALS.
Authorea, Preprint. DOI: 10.22541/au.175023624.41125652/v1