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Synonyms: DS-6000 | DS-6000A | R-DXd
Compound class:
Antibody
Comment: Raludotatug deruxtecan (R-DXd; DS-6000a) is an anti-CDH6 monoclonal conjugated to the chemotherapy agent deruxtecan (DXd; a derivative of the topoisomerase I inhibitor exatecan) [1-2]. The antitumour effect of raludotatug deruxtecan is due to intracellular release of the toxic payload; the naked antibody has no anti-tumour activity.
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| Bioactivity Comments |
| Binding affinity (Kd) for human cadherin 6 is ~65 ng/mL and for monkey cadherin 6 the value is 70 ng/mL [2]. Kd for mouse cadherin 6 is ~220 ng/mL. |
| Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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