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moxetumomab pasudotox   Click here for help

GtoPdb Ligand ID: 7675

Synonyms: CAT-8015 | GCR-8015 | HA22 | Lumoxiti® | moxetumomab pasudotox-tdfk
Approved drug Immunopharmacology Ligand
moxetumomab pasudotox is an approved drug (FDA (2018), EMA (2021))
Compound class: Antibody
Comment: Peptide sequence information for this antibody is available from its IMGT/mAb-DB link. The moxetumomab monoclonal has been mutated to increase affinity for CD22 [6] (patent WO2003027135[1]), and the antibody is fused to a 38 KDa fragment of Pseudomonas exotoxin-A (PE38) [2,4] (patent US7982011 [5]). The Uniprot accession for Pseudomonas exotoxin-A is P11439.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
Ligand families/groups Immune checkpoint modulators
Approved drug? Yes. US FDA (2018)  |  EU EMA (2021)
International Nonproprietary Names Click here for help
INN number INN
9236 moxetumomab pasudotox
Synonyms Click here for help
CAT-8015 | GCR-8015 | HA22 | Lumoxiti® | moxetumomab pasudotox-tdfk
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 198
Other databases
ChEMBL Ligand CHEMBL1743043
GtoPdb PubChem SID 223366010
Search PubMed clinical trials moxetumomab pasudotox
Search PubMed titles moxetumomab pasudotox
Search PubMed titles/abstracts moxetumomab pasudotox
Wikipedia Moxetumomab pasudotox