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nesvacumab   Click here for help

GtoPdb Ligand ID: 8457

Synonyms: REGN-910 | REGN910 | SAR307746
Compound class: Antibody
Comment: Nesvacumab is a fully human monoclonal antibody that targets angiopoietin-2 (ANGPT2, aka ANG2), being investigated as an antiangiogenic anti-tumour agent.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Bioactivity Comments
Nesvacumab is reported to disrupt Tie2-mediated signalling in preclinical studies [1].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
angiopoietin-2 Primary target of this compound Hs Antibody Binding 10.7 pKd - 1
⤷ pKd 10.7 (Kd 1.8x10-11 M) [1]