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vonlerolizumab   Click here for help

GtoPdb Ligand ID: 9245

Synonyms: MOXR 0916 | MOXR0916 | pogalizumab (deleted INN) | RG7888 | RO7021608
Compound class: Antibody
Comment: Vonlerolizumab (MOXR0916) was an investigational humanized anti-human OX40 monoclonal, with reported preclinical efficacy [1]. Genentech terminated their Phase 2 trial NCT03029832 and have discontinued further development.
Bioactivity Comments
Engagement of OX40 by MOXR0916 enhances IFN-γ production and proliferation of Teff cells, and suppresses Treg cell function in vitro [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
OX40 Primary target of this compound Hs Antibody Agonist - - - 1
⤷ [1]