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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 264 | 19p13.3 | ACER1 | alkaline ceramidase 1 | |
| Mouse | 7 | 273 | 17 D | Acer1 | alkaline ceramidase 1 | |
| Rat | - | 273 | 9q11 | Acer1 | alkaline ceramidase 1 | |
| Previous and Unofficial Names |
| Acylsphingosine deacylase 3 | Alkaline CDase 1 | AlkCDase 1 | ASAH3 | Cer1 |
| Database Links |
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| Alphafold | Q8TDN7 (Hs), Q8R4X1 (Mm) |
| BRENDA | 3.5.1.23 |
| ChEMBL Target | CHEMBL3351194 (Hs) |
| Ensembl Gene | ENSG00000167769 (Hs), ENSMUSG00000045019 (Mm), ENSRNOG00000047368 (Rn) |
| Entrez Gene | 125981 (Hs), 171168 (Mm), 301118 (Rn) |
| Human Protein Atlas | ENSG00000167769 (Hs) |
| KEGG Enzyme | 3.5.1.23 |
| KEGG Gene | hsa:125981 (Hs), mmu:171168 (Mm), rno:301118 (Rn) |
| OMIM | 613491 (Hs) |
| Pharos | Q8TDN7 (Hs) |
| RefSeq Nucleotide | NM_133492 (Hs), NM_175731 (Mm), NM_001106875 (Rn) |
| RefSeq Protein | NP_597999 (Hs), NP_783858 (Mm), NP_001100345 (Rn) |
| UniProtKB | Q8TDN7 (Hs), Q8R4X1 (Mm) |
| Wikipedia | ACER1 (Hs) |
| Enzyme Reaction |
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| Immunopharmacology Comments |
| The major biological role of ACER1 is that of maintaining skin homeostasis via regulation of keratinocyte differentiation [1]. ACER1 is included in GtoImmuPdb because of its involvement in generating the sphingolipid sphingosine, which is subsequently phosphorylated (by sphingosine kinase) to the bioactive lipid mediator S1P [3]. S1P is a major regulator of the vascular and immune systems. In the immune system S1P activation of its receptor S1P1R promotes trafficking of T and B cells from the lymphoid organs into the lymphatic vessels. |
| Tissue Distribution
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1. Coant N, Sakamoto W, Mao C, Hannun YA. (2017) Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul, 63: 122-131. [PMID:27771292]
2. Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y. (2006) Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. J Lipid Res, 47 (5): 1063-70. [PMID:16477081]
3. Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM. (2003) Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. J Biol Chem, 278 (33): 31184-91. [PMID:12783875]
target has curated data in GtoImmuPdb
