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GPR37L1

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Target not currently curated in GtoImmuPdb

Target id: 104

Nomenclature: GPR37L1

Family: Class A Orphans

This receptor has a proposed ligand; see the Latest Pairings page for more information.

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 481 1q32.1 GPR37L1 G protein-coupled receptor 37 like 1 7
Mouse 7 481 1 E4 Gpr37l1 G protein-coupled receptor 37-like 1 3
Rat 7 481 13q13 Gpr37l1 G protein-coupled receptor 37-like 1 4
Previous and Unofficial Names Click here for help
CAG-18 | endothelin B receptor-like protein 2 | ETBRLP2 | G-protein coupled receptor CNS2
Database Links Click here for help
Specialist databases
GPCRdb etbr2_human (Hs), etbr2_mouse (Mm), etbr2_rat (Rn)
Other databases
Alphafold O60883 (Hs), Q99JG2 (Mm), Q9QYC5 (Rn)
ChEMBL Target CHEMBL5892 (Hs)
Ensembl Gene ENSG00000170075 (Hs), ENSMUSG00000026424 (Mm), ENSRNOG00000006237 (Rn)
Entrez Gene 9283 (Hs), 171469 (Mm), 252939 (Rn)
Human Protein Atlas ENSG00000170075 (Hs)
KEGG Gene hsa:9283 (Hs), mmu:171469 (Mm), rno:252939 (Rn)
Pharos O60883 (Hs)
RefSeq Nucleotide NM_004767 (Hs), NM_134438 (Mm), NM_145784 (Rn)
RefSeq Protein NP_004758 (Hs), NP_602320 (Mm), NP_665727 (Rn)
UniProtKB O60883 (Hs), Q99JG2 (Mm), Q9QYC5 (Rn)
Wikipedia GPR37L1 (Hs)
Natural/Endogenous Ligands Click here for help
prosaptide {Sp: Human}
prosaposin
Comments: Proposed ligand, single publication.

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
prosaptide {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Agonist 8.3 pEC50 5
⤷ pEC50 8.3 (EC50 5x10-9 M) [5]
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family Adenylyl cyclase inhibition
Comments:  Pertussis toxin pre-treatment completely inhibited the ability of prosaptide to stimulate ERK phosphorylation in GPR37L-transfected cells [5].
References: 
Tissue Distribution Click here for help
Cerebellum, cortex, medulla, spinal cord, putamen, occipital, frontal, temporal lobes
Species:  Human
Technique:  Northern blot.
References:  7
Highly expressed in cerebellar Bergmann glia of the Purkinje cell layer, internal capsule fibers of the caudate putamen and in temporal cortex
Species:  Human
Technique:  in situ hybridisation
References:  7
Muscle-myenteric nerve layer of gastrointestinal tract
Species:  Mouse
Technique:  RT-PCR
References:  1
Tissue Distribution Comments
No transcripts of GPR37L1 were detected in peripheral tissues such as heart, placenta, lung, liver, skeletal muscle, kidney and pancreas when examined by Northen blot [7].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Ligand/receptor interaction.
Species:  Human
Tissue:  HEK-293T cells transfected with GPR37L1.
Response measured:  Internalisation of epitope-tagged receptor, ERK phosphorylation, 35S-GTPγS binding.
References:  5
Physiological Consequences of Altering Gene Expression Click here for help
Mice with GPR37L1 knockout show high blood pressure and high heart weight/ body weight (HW/BW).
Species:  Mouse
Tissue:  Heart
Technique:  knockout by gene targeting in embryonic stem cells
References:  6
Overexpression of GPR37L1 induces apoptosis of cardiomyocytes.
Species:  Mouse
Tissue:  Cardiomyocytes
Technique:  Gene overexpression
References:  6
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr37l1tm1Lex Gpr37l1tm1Lex/Gpr37l1tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J		 MGI:1928503  MP:0002169 no abnormal phenotype detected
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G90D
Global MAF (%):  16
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 25|13|19|9
Minor allele count:  G=0.160/349
SNP accession:  VAR_047456, rs3795595
Validation:  1000 Genomes, HapMap, Frequency
References:  7
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  P81A
Global MAF (%):  24
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 31|25|40|6
Minor allele count:  G=0.238/519
SNP accession:  VAR_047455, rs3795594
Validation:  1000 Genomes, HapMap, Frequency
General Comments
It is shown that folic acid supplementation decreased the expression of GPR37L1 in a dose-dependent manner [2].

References

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1. Ito J, Ito M, Nambu H, Fujikawa T, Tanaka K, Iwaasa H, Tokita S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res, 338 (2): 257-69. [PMID:19763624]

2. Junaid MA, Kuizon S, Cardona J, Azher T, Murakami N, Pullarkat RK, Brown WT. (2011) Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun, 412 (4): 688-92. [PMID:21867686]

3. Kim SJ, Shon BH, Kang JH, Hahm KS, Yoo OJ, Park YS, Lee KK. (1997) Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun, 240 (1): 239-43. [PMID:9367917]

4. Leng N, Gu G, Simerly RB, Spindel ER. (1999) Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system. Brain Res Mol Brain Res, 69 (1): 73-83. [PMID:10350639]

5. Meyer RC, Giddens MM, Schaefer SA, Hall RA. (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci USA, 110 (23): 9529-34. [PMID:23690594]

6. Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamazaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M. (2010) Identification of genes related to heart failure using global gene expression profiling of human failing myocardium. Biochem Biophys Res Commun, 393 (1): 55-60. [PMID:20100464]

7. Valdenaire O, Giller T, Breu V, Ardati A, Schweizer A, Richards JG. (1998) A new family of orphan G protein-coupled receptors predominantly expressed in the brain. FEBS Lett, 424 (3): 193-6. [PMID:9539149]

Contributors

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