<i>GPR45</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 106

Nomenclature: GPR45

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 372 2q11.1-q12 GPR45 G protein-coupled receptor 45 2
Mouse 7 373 1 C1 Gpr45 G protein-coupled receptor 45
Rat 7 373 9q22 Gpr45 G protein-coupled receptor 45
Previous and Unofficial Names
PSP24 | high-affinity lysophosphatidic acid receptor | PSP24alpha | PSP24A
Database Links
Specialist databases
GPCRDB gpr45_human (Hs), gpr45_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution
Basal forebrain, frontal cortex, caudate, liver
Species:  Human
Technique:  Northern blot
References:  2
Neuronal cells, such as olfactory mitral cells, cortical neurons, hippocampal pyramidal cells, purkinje cells in the cerebellum
Species:  Mouse
Technique:  in situ hybridisation
References:  1
Species:  Mouse
Technique:  Northern blot
References:  1
Tissue Distribution Comments
No transcripts of GPR45 were detected in thalamus, hippocampus or putamen [2]. The expression of GPR45 in mouse brain starts from E13 and remains constant throughout adulthood [1].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L312F
Global MAF (%):  10
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|12|2|16
Minor allele count:  T=0.096/209
SNP accession: 
Validation:  1000 Genomes, HapMap


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1. Kawasawa Y, Kume K, Nakade S, Haga H, Izumi T, Shimizu T. (2000) Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem. Biophys. Res. Commun., 276 (3): 952-6. [PMID:11027574]

2. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF. (1999) Discovery of three novel orphan G-protein-coupled receptors. Genomics, 56 (1): 12-21. [PMID:10036181]


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How to cite this page

Stephen P.H. Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Satoru Eguchi, Anthony Harmar, Nick Holliday, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Wen Chiy Liew, Amy E. Monaghan, Chido Mpamhanga, Richard Neubig, Adam J. Pawson, Jean-Philippe Pin, Joanna L. Sharman, Michael Spedding, Eliot Spindel, Leigh Stoddart, Laura Storjohann, Walter (Wally) Thomas, Kalyan Tirupula, Patrick Vanderheyden.
Class A Orphans: GPR45. Last modified on 16/06/2015. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=106.