Top ▲

GPR45

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 106

Nomenclature: GPR45

Family: Class A Orphans

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 372 2q12.1 GPR45 G protein-coupled receptor 45 2
Mouse 7 373 1 B Gpr45 G protein-coupled receptor 45
Rat 7 373 9q22 Gpr45 G protein-coupled receptor 45
Previous and Unofficial Names Click here for help
PSP24 | high-affinity lysophosphatidic acid receptor | PSP24alpha | PSP24A
Database Links Click here for help
Specialist databases
GPCRDB gpr45_human (Hs), gpr45_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution Click here for help
Basal forebrain, frontal cortex, caudate, liver
Species:  Human
Technique:  Northern blot
References:  2
Neuronal cells, such as olfactory mitral cells, cortical neurons, hippocampal pyramidal cells, purkinje cells in the cerebellum
Species:  Mouse
Technique:  in situ hybridisation
References:  1
Brain
Species:  Mouse
Technique:  Northern blot
References:  1
Tissue Distribution Comments
No transcripts of GPR45 were detected in thalamus, hippocampus or putamen [2]. The expression of GPR45 in mouse brain starts from E13 and remains constant throughout adulthood [1].
Expression Datasets Click here for help

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L312F
Global MAF (%):  10
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|12|2|16
Minor allele count:  T=0.096/209
SNP accession: 
Validation:  1000 Genomes, HapMap

References

Show »

1. Kawasawa Y, Kume K, Nakade S, Haga H, Izumi T, Shimizu T. (2000) Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem. Biophys. Res. Commun., 276 (3): 952-6. [PMID:11027574]

2. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF. (1999) Discovery of three novel orphan G-protein-coupled receptors. Genomics, 56 (1): 12-21. [PMID:10036181]

Contributors

Show »

How to cite this page