GPR52
Target not currently curated in GtoImmuPdb
Target id: 108
Nomenclature: GPR52
Family: Class A Orphans
Annotation status:
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Contents:
Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 361 | 1q24 | GPR52 | G protein-coupled receptor 52 | 2 |
| Mouse | 7 | 361 | 1 H2.1 | Gpr52 | G protein-coupled receptor 52 | |
| Rat | 7 | 361 | 13q22 | Gpr52 | G protein-coupled receptor 52 | |
| Database Links |
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| Specialist databases | |
| GPCRDB | gpr52_human (Hs), gpr52_mouse (Mm) |
| Other databases | |
| ChEMBL Target | CHEMBL3297639 (Hs), CHEMBL4105791 (Mm) |
| Ensembl Gene | ENSG00000203737 (Hs) |
| Entrez Gene | 9293 (Hs), 620246 (Mm), 680192 (Rn) |
| Human Protein Atlas | ENSG00000203737 (Hs) |
| KEGG Gene | hsa:9293 (Hs), mmu:620246 (Mm), rno:680192 (Rn) |
| OMIM | 604106 (Hs) |
| RefSeq Nucleotide | NM_005684 (Hs), NM_001146330 (Mm) |
| RefSeq Protein | NP_005675 (Hs), NP_001139802 (Mm) |
| UniProtKB | Q9Y2T5 (Hs), P0C5J4 (Mm) |
| Wikipedia | GPR52 (Hs) |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Tissue Distribution
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| General Comments |
| GPR52 has four potential N-linked glysosylation sites, five PKA/PKC and six PKC intracellular phosphorylation sites and three putative C-tail palmitoylation sites [2]. |
References
1. Nakahata T, Tokumaru K, Ito Y, Ishii N, Setoh M, Shimizu Y, Harasawa T, Aoyama K. Design and Synthesis of 1-(1-Benzothiophen-7-yl)-1H-Pyrazole, a Novel Series of G Protein-coupled Receptor 52 (GPR52) Agonists. Bioorganic & Medicinal Chemistry, In Press, Accepted Manuscript.
2. Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF. (1999) Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. Brain Res. Mol. Brain Res., 64 (2): 193-8. [PMID:9931487]
3. Setoh M, Ishii N, Kono M, Miyanohana Y, Shiraishi E, Harasawa T, Ota H, Odani T, Kanzaki N, Aoyama K et al.. (2014) Discovery of the first potent and orally available agonist of the orphan G-protein-coupled receptor 52. J. Med. Chem., 57 (12): 5226-37. [PMID:24884590]
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