Fatty acid transport protein 1 | SLC27 family of fatty acid transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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Fatty acid transport protein 1

Target not currently curated in GtoImmuPdb

Target id: 1108

Nomenclature: Fatty acid transport protein 1

Abbreviated Name: FATP1

Systematic Nomenclature: SLC27A1

Family: SLC27 family of fatty acid transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC27A1 solute carrier family 27 member 1
Mouse - - Slc27a1 solute carrier family 27 (fatty acid transporter)
Rat - - Slc27a1 solute carrier family 27 member 1
Previous and Unofficial Names
Long-chain fatty acid transport protein 1 | solute carrier family 27 member 1 | ACSVL5 | FATP | solute carrier family 27 (fatty acid transporter), member 1 | solute carrier family 27 (fatty acid transporter)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC27A1 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Endogenous substrates (Human)
arachidonic acid > palmitic acid > oleic acid > butyric acid  [3]
Endogenous substrates (Human)
palmitic acid > oleic acid > γ-linolenic acid > octanoic acid  [1]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5k [PMID: 23528296] Hs Inhibition 7.3 pIC50 2
pIC50 7.3 (IC50 4.6x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
GO:0033211 adiponectin-activated signaling pathway IBA

References

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1. Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A. (2003) Characterization of a heart-specific fatty acid transport protein. J. Biol. Chem., 278 (18): 16039-44. [PMID:12556534]

2. Matsufuji T, Ikeda M, Naito A, Hirouchi M, Kanda S, Izumi M, Harada J, Shinozuka T. (2013) Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg. Med. Chem. Lett., 23 (9): 2560-5. [PMID:23528296]

3. Schaffer JE, Lodish HF. (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell, 79 (3): 427-36. [PMID:7954810]

Contributors

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