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GPR62

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Target not currently curated in GtoImmuPdb

Target id: 111

Nomenclature: GPR62

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 368 3p21.2 GPR62 G protein-coupled receptor 62 1
Mouse 7 358 9 F1 Gpr62 G protein-coupled receptor 62
Rat - 358 8q32 Gpr62 G protein-coupled receptor 62
Previous and Unofficial Names Click here for help
GPCR8
Database Links Click here for help
Specialist databases
GPCRdb gpr62_human (Hs), gpr62_mouse (Mm), d4a2b1_rat (Rn)
Other databases
Alphafold Q9BZJ7 (Hs), Q80UC6 (Mm), D4A2B1 (Rn)
ChEMBL Target CHEMBL4523917 (Hs)
Ensembl Gene ENSG00000180929 (Hs), ENSMUSG00000091735 (Mm), ENSRNOG00000022567 (Rn)
Entrez Gene 118442 (Hs), 436090 (Mm), 501049 (Rn)
Human Protein Atlas ENSG00000180929 (Hs)
KEGG Gene hsa:118442 (Hs), mmu:436090 (Mm), rno:501049 (Rn)
OMIM 606917 (Hs)
Pharos Q9BZJ7 (Hs)
RefSeq Nucleotide NM_080865 (Hs), NM_001159652 (Mm), XM_576464 (Rn)
RefSeq Protein NP_543141 (Hs), NP_001153124 (Mm), XP_576464 (Rn)
UniProtKB Q9BZJ7 (Hs), Q80UC6 (Mm), D4A2B1 (Rn)
Wikipedia GPR62 (Hs)
Tissue Distribution Click here for help
Brain regions (basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen)
Species:  Human
Technique:  Northern blot
References:  1
Tissue Distribution Comments
Transcripts of GPR62 were not detected in the liver when examined by Northern blot analysis [1].
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V313L
Global MAF (%):  11
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 36|3|8|2
Minor allele count:  C=0.113/247
SNP accession:  rs323871
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S365R
Global MAF (%):  1
Subpopulation MAF (%):  AFR: 5
Minor allele count:  G=0.011/24
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs116027996
Validation:  1000 Genomes, Frequency
General Comments
GPR62 has higher expression in the brain, indicating its cognate ligand may be a neurotransmitter [1].

References

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1. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF. (2001) Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Res Mol Brain Res, 86 (1-2): 13-22. [PMID:11165367]

Contributors

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